Yang, Z.;^# Kou, S.;^# Wei, X.; Zhang, F.; Li, F.; Wang, X.-W.; Lin, Y.; Wan, C.;* Zhang, W.-B.;* Sun, F.* Genetically Programming Stress-Relaxation Behavior in Entirely Protein-Based Molecular Networks. ACS Macro Lett. 2018, 7 , 1468-1474.

Abstract: We report the synthesis of a series of elastin-like polypeptide (ELP)-based molecular networks through the combined use of the covalent bond-forming SpyTag/SpyCatcher chemistry, physically entangled p53dim domains (Xs), and site-directed mutagenesis. The resulting networks shared similar chemical composition but differed significantly in their viscoelasticity. These materials exhibited excellent compatibility toward encapsulated fibroblasts and stem cells. These results point to a versatile strategy for designing viscoelastic materials by tapping into diverse protein–protein interactions.