箴言
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在科学上没有平坦的大道,只有那些不畏艰险沿着陡峭山路攀登的人,才有希望达到光辉的顶点。
----马克思
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请有兴趣的研究组联系我们。欢迎任何形式的合作，尤其是在自组装、水凝胶以及生物医药等方向的合作。
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研究成果
76. Giant Molecules: Where Chemistry, Physics, and Bio-Science Meet. Sci. China. Chem. 2017, 60, 338-352
发布时间:2017-03-23
Guang-Zhong Yin, Wen-Bin Zhang, SZD Cheng. Giant Molecules: Where Chemistry, Physics, and Bio-Science Meet. 2017, 60(3), 338-352. [Link]
Abstract:
This feature article focuses on the recent development of giant molecules, which has emerged at the interface among chemistry, physics, and bio-science. Their molecular designs are inspired by natural polymers like proteins and are modularly constructed from molecular nanoparticle building blocks via sequential “click” chemistry. Most important molecular parameters such as topology, composition, and molecular weight can be precisely controlled. Their hierarchical assembly reveals many features reminiscent of both small molecules and proteins yet unusual for conventional synthetic polymers. These features are summarized and compared along with synthetic polymers and proteins. Specifically, examples are given in each category of giant molecules to illustrate the characteristics of their hierarchical assembly across different length, time and energy scales. The idea of “artificial domain” is presented in analogy to the structural domains in proteins. By doing so, we aim to develop a rational and modular approach toward functional materials. The factors that dominate the materials functions are discussed with respect to the precision and dynamics of the assembly. The complexity of structure-function relationship is acknowledged, which suggests that there is still a long way to go toward the convergence of synthetic polymers and biopolymers.
This feature article focuses on the recent development of giant molecules, which has emerged at the interface among chemistry, physics, and bio-science. Their molecular designs are inspired by natural polymers like proteins and are modularly constructed from molecular nanoparticle building blocks via sequential “click” chemistry. Most important molecular parameters such as topology, composition, and molecular weight can be precisely controlled. Their hierarchical assembly reveals many features reminiscent of both small molecules and proteins yet unusual for conventional synthetic polymers. These features are summarized and compared along with synthetic polymers and proteins. Specifically, examples are given in each category of giant molecules to illustrate the characteristics of their hierarchical assembly across different length, time and energy scales. The idea of “artificial domain” is presented in analogy to the structural domains in proteins. By doing so, we aim to develop a rational and modular approach toward functional materials. The factors that dominate the materials functions are discussed with respect to the precision and dynamics of the assembly. The complexity of structure-function relationship is acknowledged, which suggests that there is still a long way to go toward the convergence of synthetic polymers and biopolymers.