Congratulations to Prof. Zhang's work accepted by Angew. Chem. Int. Ed.!

The title is Sequence Mandated, Distinct Assembly of Giant Molecules.

Abstract
Although controlling primary structures is by itself an enormous challenge for synthetic polymers, the potential of sequence control for tailoring hierarchical structures remains to be exploited, especially in the creation of new and unconventional phases. Herein, we design a series of model amphiphilic chain-like giant molecules by connecting both hydrophobic and hydrophilic molecular nanoparticles in precisely defined sequence and composition to investigate their intriguing sequence-dependent phase structures. Not only has composition changed the self-assembled phases, but also specific sequences are found to induce unconventional phase formation, including Frank-Kasper phases. The formation mechanism has been attributed to the conformational change driven by the collective hydrogen bonding and the sequence-mandated topology of the molecules. These results support that sequence-control in synthetic polymers can have dramatic impacts on the polymer properties and self-assembly.

Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.201709354/abstract