研究室工作进展 Apr 15th, 2011
研究室工作进展 Apr 26th, 2011
Palladium-Catalyzed, One-Pot, Three-Component Approach to a-Alkynyl Indoles from o-Bromo-(2,2-dibromovinyl)benzenes, Terminal Alkynes and Arylamines
Yun Liang, Tianhao Meng, Hui-Jun Zhang, Zhenfeng Xi*
Synlett 2011, 911–914
Dedicated to Professor Xiyan Lu and Professor Lixin Dai
a-Alkynyl indoles were efficiently synthesized in one pot from o-bromo- (2,2-dibromovinyl)benzenes, terminal alkynes, and arylamines via a palladium-catalyzed three-component coupling process.
We are recently working on the preparation and synthetic applications of polyhalo compounds, expecting cooperative effect among those polyfunctional groups.
背景介绍：
本研究室开展了双金属有机试剂研究。作为双金属有机试剂研究的基础，我们建立了一些合成多官能团有机化合物如多卤和多硼化合物的方法。为了进一步拓展这些多卤和多硼化合物在有机合成中的应用，发现多官能团在反应中的协同效应，我们开展了过渡金属催化的交叉偶联反应研究。本论文是相关工作之一。