研究室工作进展 Sept 10th, 2009
Zirconium- and Silicon-Containing Intermediates with Three Fused Rings in a Zirconocene-Mediated Intermolecular Coupling Reaction
Wen-Xiong Zhang, Shaoguang Zhang, Xiaohua Sun, Masayoshi Nishiura,
Zhaomin Hou,* and Zhenfeng Xi*
Angew. Chem. Int. Ed. 2009, 48, 7227-7231.
Veritable Jack-in-the-box: The isolation and characterization of key Zr/Si-containing intermediates was achieved for a zirconocene-mediated intermolecular coupling reaction (see scheme). The fate of the various functional groups was determined, and the reactivity of intermediate with a variety of unsaturated substrates was also investigated.
This work demonstrates that the isolation and reactivity investigation ofreactive organometallic intermediates are not only of importance and interest for the in-depth understanding of seemingly complicated reaction mechanisms,but can alsolead to the discovery of new synthetic methods.