研究室工作进展 Ooc. 2 nd 2009
Efficient One-Pot Synthesis of 2,3-Dihydropyrimidinthiones via Multicomponent Coupling of Terminal Alkynes, Elemental Sulfur and Carbodiimides
Zitao Wang, Yang Wang, Wen-Xiong Zhang,* Zhaomin Hou, and Zhenfeng Xi*
J. Am. Chem. Soc. 2009, ASAP online October 2
An organolithium-promoted MCR involving readily available terminal alkynes, elemental sulfur, and carbodiimides has been achieved for the first time, which offers an atom-economic route to 2,3-dihydropyrimidinones that were difficult to access by other means via an interesting and useful C=N double bond cleavage and an sp3 C-H bond functionalization of carbodiimides.