罗海

博士, 副教授, 博士生导师

分析化学，质谱科学和技术

电话: +86-10-62751499

传真: +86-10-62751708

电子信箱: hluo@pku.edu.cn

学术简历：

2000，美国普渡大学，分析化学，博士(导师：R. Graham Cooks, Michael J. Weaver)

1994，美国西弗吉尼亚大学，物理化学，硕士(导师：Naresh S. Dalal)

1990，中国科学技术大学，高分子化学，学士(导师：汪月生,张其锦)

2005 -至今，伟德国际1946官网，副教授

2002 - 2004，美国雅培公司生命研究中心，研究员

2000 - 2002，美国太平洋西北国家实验室，博士后

1990 - 1992，中国科学院大连化学物理研究所，研习员

教学工作：

分析化学Seminar（研究生），分析化学（B）以及实验课（本科生）

研究领域和兴趣：

1. 质谱离子化技术和分析方法的发展及应用

2. 新型质谱离子源上的原位化学反应和应用

3. 非共价复合物和超分子团簇离子的气相化学和表征

主持国家自然科学基金项目情况：

1. 国家自然科学基金面上项目，21874002，新型电化学-质谱平台及其在电化学反应机理研究中的应用，2019/01-2022/12，64万元，在研

2. 国家自然科学基金应急管理项目，21445005，快速蒸发多通道旋转质谱离子源的设计、构建和在生物组织诊断上的基础应用研究，2015/01-2015/12，10万元，已结题，主持

3. 国家自然科学基金面上项目，21075005，基于脲嘧啶和胸腺嘧啶五联体的新型非共价自组装体系的研究，2011/01-2013/12，35万元，已结题，主持

4. 国家自然科学基金科学仪器基础研究专项基金项目，20727002，喷雾辅助激光解吸环境电离源的设计、构建和基础应用研究，2008/01-2010/12，160万元，已结题，主持

5. 国家自然科学基金面上项目，20575006，电喷雾电离质谱方法在表面和生化分析中的应用基础研究，2006/01-2008/12，28万元，已结题，主持

代表性论文：

(1) Ran Qiu#, Xin Zhang#, Hai Luo*, Yuanhua Shao*, Mass spectrometric snapshots for electrochemical reactions, Chemical Science, 2016, 7(11): 6684-6688.

(2) Ran Qiu, Jiamu Sun, Chengsen Zhang*, Hai Luo*, Heterogeneous cation induced clusters formed at surfaces of micro-droplets, RSC Advances, 2016, 6(53): 47997-48000.

(3) Ran Qiu, Chengsen Zhang*, Zhen Qin, Hai Luo*,A multichannel rotating electrospray ionization mass spectrometry (MRESI): instrumentation and plume interactions, RSC Advances, 2016, 6(43): 36615-36622.

(4) Ran Qiu#, Jiamu Sun#, Xin Zhang, Wenbo Zhao, Zhen Qin*, Hai Luo*, Isomer differentiation through supramolecular self-assembly in microdroplets of milliseconds life-time, Analyst, 2016, 141(5): 1641-1644.

(5) Ran Qiu, Hai Luo*, Copper (I)-triazole dimer formation and rate acceleration in in-source click reaction, RSC Advances, 2015, 5(116): 96213-96221.

(6) 任昕昕, 邱然, 罗海*,高电压辅助激光解吸附离子化质谱中盐效应的研究, 分析化学，2014，42(11): 1697-1701.

(7) Wenbo Zhao, Zhen Qin, Chengsen Zhang, Meiping Zhao*, Hai Luo*, A label-free double amplification system for sensitive detection of single-stranded DNA and thrombin by liquid chromatography-mass spectrometry, Chemical Communications, 2014, 50(69): 9846-9848.

(8) Ran Qiu, Hai Luo*, Reaction and detection click in high-voltage assisted laser desorption ionization mass spectrometry, Analyst, 2014, 139(15): 3706-3708.

(9) Jiamu Sun, Zhen Qin, Jia Liu, Chengsen Zhang, Hai Luo*, Highly sensitive and specific detection of histamine via the formation of a self-assembled magic number cluster with thymine by mass spectrometry, Analyst, 2014, 139(12): 3154-3159.

(10) Zhen Qin, Bo Qiu, Jiamu Sun, Wenbo Zhao, Hai Luo*, Protonated primary amines induced thymine quintets studied by electrospray ionization mass spectrometry and density functional theory calculations, Journal of Mass Spectrometry, 2014, 49(4): 266-273.

(11) Xinxin Ren, Jia Liu, Chengsen Zhang, Jiamu Sun, Hai Luo*, Signal enhancement of carboxylic acids by inclusion with β-cyclodextrin in negative high-voltage-assisted laser desorption ionization mass spectrometry, Rapid Communications in Mass Spectrometry, 2014, 28(1): 115-122.

(12) Xinxin Ren, Jia Liu, Chengsen Zhang, Hai Luo*, Direct analysis of samples under ambient condition by high-voltage assisted laser desorption ionization mass spectrometry in both positive and negative ion mode, Rapid Communications in Mass Spectrometry, 2013, 27(5): 613-620.

(13) Jia Liu, Chengsen Zhang, Jiamu Sun, Xinxin Ren, Hai Luo*, Laser desorption dual-spray post-ionization mass spectrometry for direct analysis of samples via two informative channels, Journal of Mass Spectrometry, 2013, 48(2): 250-254.

(14) REN Xin-Xin, LIU Jia, ZHANG Cheng-Sen, LUO Hai*, Rapid and direct analysis of active ingredients in tablets using atmospheric pressure laser desorption ionization mass spectrometry, Chinese Journal of Analytical Chemistry, 2013, 41(3): 366-370.

(15) Zhen Qin, Jia Liu, Bo Qiu, Hai Luo*, Reactive desorption electrospray ionization mass spectrometry of self-assembled quintets of uracil and its homologues, Journal of Mass Spectrometry, 2012, 47(5): 552-554.

(16) Jia Liu, Chengsen Zhang, Jiamu Sun, Hai Luo*, Unexpected complexation reaction during analysis of proteins using laser desorption spray post-ionization mass spectrometry, Analyst, 2012, 137(8): 1764-1767.

(17) Bo Qiu, Zhen Qin, Jia Liu, Hai Luo*, Thymine quintets and their higher order assemblies studied by electrospray ionization mass spectrometry and theoretical calculation, Journal of Mass Spectrometry, 2011, 46(6): 587-594.

(18) Congfang Lai, Guangxin Lin, Wenyue Wang, Hai Luo*, Absolute configurations and stability of cyclic guanosine mono-adducts with glyoxal and methylglyoxal, Chirality, 2011, 23(7): 487-494.

(19) Jia Liu, Bo Qiu, Hai Luo*, Fingerprinting of yogurt products by laser desorption spray post-ionization mass spectrometry, Rapid Communications in Mass Spectrometry, 2010, 24(9): 1365-1370.

(20) Guangxin Lin, Jing Zhang, Yu Zeng, Hai Luo*, Yinsheng Wang*, Conformation dependent formation of theG[8-5]U intrastrand cross-link in 5-bromouracil-containing G-quadruplex DNA induced by UVA irradiation, Biochemistry, 2010, 49(11): 2346-2350.

(21) Bo Qiu, Jia Liu, Zhen Qin, Guanbo Wang, and Hai Luo*, Quintets of uracil and thymine: a novel structure of nucleobase self-assembly studied by electrospray ionization mass spectrometry, Chemical Communications, 2009, (20): 2863-2865.

(22) Bo Qiu, and Hai Luo*, Desorption electrospray ionization mass spectrometry of DNA nucleobases: implications for a liquid film model, Journal of Mass Spectrometry, 2009, 44(5): 772-779.

(23) Congfang Lai, Huachuan Cao, John E. Hearst, Laurence Corash, Hai Luo*, and Yinsheng Wang*, Quantitative analysis of DNA interstrand cross-links and monoadducts formed in human cells induced by psoralens and UVA irradiation, Analytical Chemistry, 2008, 80(22): 8790-8798.

(24) 薛震，邱波，林广欣，赖丛芳，罗海*,解吸电喷雾电离技术,化学进展, 2008, 20(4): 594-601.

已授权专利：

(1) 张成森，罗海，邱然，一种多通道旋转萃取电喷雾离子化质谱分析离子源，2015.01.14，中国，ZL201210202005.3

(2) 张成森，罗海，多通道旋转电喷雾离子化质谱分析离子源，2014.07.02，中国, ZL201110422357.5

(3) 张成森，罗海，刘佳，秦震，质谱多通道旋转电喷雾离子源，2013.03.06，中国，ZL201110240135.1

(4) 张成森，罗海，任昕昕，刘佳，一种高压辅助激光解吸离子化质谱分析离子源，2012.07.18，中国，ZL201120498921.7

(5) 张成森，罗海，秦震，刘佳，质谱双离子源安装平台装置，2011.12.07，中国，ZL201120134522.2

(6) 罗海，刘佳，邱波，质谱离子传输管外延长接口装置，2010.05.12，中国，ZL200920108393.2