Jian  Lin 

Manager, Synthetic and Functional Biomolecules Center (SFBC), Peking University
Associate Professor, Synthetic and Functional Biomolecules Center (SFBC), Peking University

Education and Research Background

Jian Lin, born in 1977 in Shaoyang, China. Dr. Lin obtained his B.S. degree in Biology from Peking University in 1998 and his Ph.D. degree in Genetics from Beijing Institute of Biotechnology in 2004 . After a postdoctoral training with Prof. George F. Gao at Institute of Microbiology in 2004-2006, he joined the group of Professor Bin Xia as a Co-Investigator at Peking University since 2006. In 2012 he joined SFBC as an associated professor.

Research Direction and Achievements

My research will focus on the mechanisms of novel compounds that selectively kill cancer cells. Our research directions include:
• Discovery of novel compounds that selectively induce cancer cell death;
• Potential genes and signal pathways that participate in cancer cell death;
• Identification of new targets in cancer therapy.

Recent Publications

1. Jin Y, Chen C, Meng L, Chen J, Li M, Zhu Z, Lin J*. A CE-LIF method to monitor autophagy by directly detecting LC3 proteins in HeLa cells. Analyst. 2012. 137:5571-5.
2. Zhou C, ZhongW, Zhou J, Sheng F, Fang Z, Wei Y, Chen Y, Deng X, Xia B, Lin J*. Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells. Autophagy. 2012. 8:1215-26.
3. Lin J, Wang N, Li Y, Liu Z, Tian S, Zhao L, Zheng Y, Liu S, Li S, Jin C, Xia B. LEC-BiFC: a new method for rapid assay of protein interaction. Biotech Histochem. 2011. 86:272-9. (Cover)
4. Zhou J, Lin J, Zhou C, Deng X, Xia B. Cytotoxicity of red fluorescent protein DsRed is associated with the suppression of Bcl-xL translation. FEBS L. 2011. 585:821-7. (Co-first author)
5. Zhou J, Lin J, Zhou C, Deng X, Xia B. An improved bimolecular fluorescence complementation tool based on superfolder green fluorescent protein. Acta Biochim Biophys Sin. 2011. 43:239-44. (Co-first author) (Cover)
6. Tian S, Lin J, Zhou J, Wang X, Li Y, Ren X, Yu W, Zhong W, Xiao J, Sheng F, Chen Y, Jin C, Li S, Zheng Z, Xia B. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy. 2010，6:1032-41. (Co-first author)
7. Ren X, Lin J*, Jin C, Xia B*. Solution structure of the N-terminal catalytic domain of human H-REV107 - a novel circular permutated NlpC/P60 domain. FEBS L. 2010, 584: 4222-6. (Co-corresponding author)
8. Lin J, Zheng Z, Li Y, Yu W, Zhong W, Tian S, Zhao F, Ren X, Xiao J, Wang N, Liu S, Wang L, Sheng F, Chen Y, Jin C, Li S and Xia B. A novel Bcl-xL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy. 2009. 5:314-20.
9. Lin J, Jin R, Zhang B, Chen H, Bai Y, Yang P, Han S, Xie Y, Huang P, Huang C, Huang J. Nucleolar localization of TERT is unrelated to telomerase function in human cells. J Cell Sci. 2008. 121:2169-76.
10. Lin J, Jin R, Zhang B, Yang P, Chen H, Bai Y, Xie Y, Huang C, Huang J. Characterization of a novel effect of hPinX1 on hTERT nucleolar localization. Biochem Biophys Res Commun. 2007. 353:946-52.